Nigel G Laing Selected Research

Cofilin 2

9/2014	Novel cofilin-2 (CFL2) four base pair deletion causing nemaline myopathy.
1/2007	Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2.

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Nigel G Laing Research Topics

Disease

26	Nemaline Myopathies (Nemaline Myopathy) 01/2020 - 09/2003
26	Muscular Diseases (Myopathy) 01/2019 - 09/2003
4	Arthrogryposis 01/2018 - 02/2013
4	Distal Myopathies (Distal Muscular Dystrophy) 12/2015 - 10/2004
4	Myosin Storage Myopathy 07/2014 - 10/2004
4	Muscle Weakness 01/2012 - 01/2005
3	Multiple pterygium syndrome 06/2017 - 02/2013
3	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 08/2014 - 09/2010
3	Congenital Structural Myopathies (Centronuclear Myopathy) 08/2014 - 11/2004
3	Cap Myopathy 07/2014 - 06/2007
3	Myofibrillar Myopathy 06/2011 - 02/2004
2	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2022 - 12/2015
2	type 1 Pena Shokeir syndrome 12/2018 - 06/2017
2	Rare Diseases (Rare Disease) 01/2018 - 01/2017
2	Muscular Dystrophies (Muscular Dystrophy) 12/2015 - 01/2015
2	Central Core Myopathy (Central Core Disease) 10/2007 - 12/2004
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2022
1	Fasciculation (Fasciculations) 10/2020
1	Aphasia (Dysphasia) 02/2020
1	Patent Ductus Arteriosus 02/2020
1	Congenital Mydriasis 02/2020
1	Chorea (Rheumatic Chorea) 02/2020
1	Disease Progression 01/2020
1	Glycogen Storage Disease Type V (McArdle's Disease) 01/2020
1	Vaccinia 11/2019
1	Muscular Atrophy (Muscle Atrophy) 11/2019
1	Neoplasms (Cancer) 01/2019
1	Atrophy 01/2018
1	Cystinosis 09/2017
1	Atrial Fibrillation 01/2017
1	Neuromuscular Diseases (Neuromuscular Disease) 11/2015
1	Hypokinesia (Bradykinesia) 11/2015
1	Ketosis 08/2013
1	Hyperglycemia 08/2013
1	Contracture 02/2013
1	Sarcoma (Soft Tissue Sarcoma) 12/2012
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 08/2011
1	Pathological Protein Aggregation 06/2011
1	Inclusion Body Myositis 06/2011
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 09/2010
1	Cardiomegaly (Heart Hypertrophy) 04/2010
1	Hypertrophy 04/2010
1	Ophthalmoplegia (External Ophthalmoplegia) 12/2008
1	Respiratory Insufficiency (Respiratory Failure) 06/2007
1	Facies 06/2007

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2004
9	Actins (F Actin)IBA 09/2010 - 09/2003
8	nebulinIBA 01/2020 - 09/2004
7	TropomyosinIBA 07/2014 - 01/2005
6	Myosins (Myosin)IBA 08/2014 - 10/2004
4	Protein Isoforms (Isoforms)IBA 07/2014 - 08/2004
3	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2017 - 12/2004
3	CalciumIBA 01/2017 - 04/2010
2	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 11/2015
2	Tyrosine (L-Tyrosine)FDA Link 01/2018 - 10/2006
2	Cofilin 2IBA 09/2014 - 01/2007
2	Cardiac MyosinsIBA 07/2014 - 10/2007
2	Myosin Heavy Chains (Myosin Heavy Chain)IBA 07/2009 - 10/2004
2	Protein AggregatesIBA 07/2009 - 02/2004
1	LaminsIBA 01/2022
1	Neuregulin-1 (Neuregulin 1)IBA 01/2022
1	Creatine Kinase (Creatine Phosphokinase)IBA 10/2020
1	Retinaldehyde (Retinal)IBA 02/2020
1	GlycogenIBA 01/2020
1	EnzymesIBA 01/2020
1	Glycogen Phosphorylase (Phosphorylase, Glycogen)IBA 01/2020
1	Nonsense Codon (Nonsense Mutation)IBA 01/2020
1	Phosphotransferases (Kinase)IBA 11/2019
1	Nuclear Pore Complex Proteins (Nucleoporins)IBA 12/2018
1	TroponinIBA 01/2018
1	MyostatinIBA 01/2018
1	Cystine (L-Cystine)IBA 09/2017
1	Cysteamine (Mercaptamine)FDA Link 09/2017
1	RNA (Ribonucleic Acid)IBA 01/2017
1	Oxidoreductases (Dehydrogenase)IBA 11/2016
1	Ventricular MyosinsIBA 12/2015
1	CollagenIBA 12/2015
1	Choline KinaseIBA 01/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 08/2014
1	myotubularinIBA 08/2014
1	LipidsIBA 08/2014
1	Cytochromes c1 (Cytochrome c1)IBA 08/2013
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 08/2013
1	Insulin (Novolin)FDA Link 08/2013
1	1,4-alpha-Glucan Branching Enzyme (Glycogen Branching Enzyme)IBA 02/2013
1	ActomyosinIBA 12/2012
1	FilaminsIBA 06/2011
1	HLA-B Antigens (HLA-B)IBA 06/2011
1	HLA-DRB1*03:01 antigenIBA 06/2011
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 04/2010
1	Mutant Proteins (Protein, Mutant)IBA 09/2008
1	Selenoproteins (Selenoprotein)IBA 10/2007
1	Actin Depolymerizing Factors (Cofilins)IBA 10/2007
1	Microfilament Proteins (Actin Binding Proteins)IBA 01/2007
1	Codon (Codons)IBA 10/2006

Therapy/Procedure

5	Therapeutics 01/2020 - 08/2011
1	Ligation 02/2020
1	Noninvasive Ventilation 01/2019
1	Precision Medicine 01/2019
1	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 08/2014